Supercharged precision killers: Genetically engineered biomimetic drugs of screened metalloantibiotics against Acinetobacter baumanni.

To eliminate multidrug-resistant bacteria of Acinetobacter baumannii, we screened 1100 Food and Drug Administration-approved small molecule drugs and accessed the broxyquinoline (Bq) efficacy in combination with various metal ions. Antibacterial tests demonstrated that the prepared Zn(Bq)2 complex showed ultralow minimum inhibitory concentration of ~0.21 micrograms per milliliter with no resistance after 30 passages. We then constructed the nano zeolitic imidazolate framework-8 (ZIF-8) as a drug carrier of Zn(Bq)2 and also incorporated the photosensitizer chlorin e6 (Ce6) to trace and boost the antibacterial effect. To further ensure the stable and targeted delivery, we genetically engineered outer membrane vesicles (OMVs) with the ability to selectively target A. baumannii. By coating the ZnBq/Ce6@ZIF-8 core with these OMV, the resulted drug (ZnBq/Ce6@ZIF-8@OMV) exhibited exceptional killing efficacy (>99.9999999%) of A. baumannii. In addition, in vitro and in vivo tests were also respectively carried out to inspect the remarkable efficacy of this previously unknown nanodrug in eradicating A. baumannii infections, including biofilms and meningitis.

Size characterization of x-ray tube source with sphere encoded imaging method.

In x-ray imaging, the size of the x-ray tube light source significantly impacts image quality. However, existing methods for characterizing the size of the x-ray tube light source do not meet measurement requirements due to limitations in processing accuracy and mechanical precision. In this study, we introduce a novel method for accurately characterizing the size of the x-ray tube light source using spherical encoded imaging technology. This method effectively mitigates blurring caused by system tilting, making system alignment and assembly more manageable. We employ the Richardson-Lucy algorithm to iteratively deconvolve the image and recover spatial information about the x-ray tube source. Unlike traditional coded imaging methods, spherical coded imaging employs high-Z material spheres as coding elements, replacing the coded holes used in traditional approaches. This innovation effectively mitigates blurring caused by system tilting, making system alignment and assembly more manageable. In addition, the mean square error is reduced to 0.008. Our results demonstrate that spherical encoded imaging technology accurately characterizes the size of the x-ray tube light source. This method holds significant promise for enhancing image quality in x-ray imaging.

High performance on-chip polarization beam splitter at visible wavelengths based on a silicon nitride small-sized ridge waveguide.

Due to sensitive scaling of the wavelength and the visible-light absorption properties with the device dimension, traditional passive silicon photonic devices with asymmetric waveguide structures cannot achieve polarization control at the visible wavelengths. In this work, a simple and small polarization beam splitter (PBS) for a broad visible-light band, using a tailored silicon nitride (Si3N4) ridge waveguide, is presented, which is based on the distinct optical distribution of two fundamental orthogonal polarized modes in the ridge waveguide. The bending loss for different bending radii and the optical coupling properties of the fundamental modes for different Si3N4 ridge waveguide configurations are analyzed. A PBS composed of a bending ridge waveguide structure and a triple-waveguide directional coupler was fabricated on the Si3N4 thin film. The TM excitation of the device based on a bending ridge waveguide structure shows a polarization extinction ratio (PER) of ≥ 20 dB with 33 nm bandwidth (624-657 nm) and insertion loss (IL) ≤ 1 dB at the through port. The TE excitation of the device, based on a triple-waveguide directional coupler with coupling efficiency distinction between the TE0 and TM0 modes, shows a PER of ≥ 18 dB with 50 nm bandwidth (580-630 nm) and insertion loss (IL) ≤ 1 dB at the cross port. The on-chip Si3N4 PBS device is found to possess the highest known PER at a visible broadband range and small (43 µm) footprint. It should be useful for novel photonic circuit designs and further exploration of Si3N4 PBSs.

Polarization Splitting at Visible Wavelengths with the Rutile TiO2 Ridge Waveguide.

On-chip polarization control is in high demand for novel integrated photonic applications such as polarization division multiplexing and quantum communications. However, due to the sensitive scaling of the device dimension with wavelength and the visible-light absorption properties, traditional passive silicon photonic devices with asymmetric waveguide structures cannot achieve polarization control at visible wavelengths. In this paper, a new polarization-splitting mechanism based on energy distributions of the fundamental polarized modes in the r-TiO2 ridge waveguide is investigated. The bending loss for different bending radii and the optical coupling properties of the fundamental modes in different r-TiO2 ridge waveguide configurations are analyzed. In particular, a polarization splitter with a high extinction ratio operating at visible wavelengths based on directional couplers (DCs) in the r-TiO2 ridge waveguide is proposed. Polarization-selective filters based on micro-ring resonators (MRRs) with resonances of only TE or TM polarizations are designed and operated. Our results show that polarization-splitters for visible wavelengths with a high extinction ratio in DC or MRR configurations can be achieved with a simple r-TiO2 ridge waveguide structure.

Temperature-immune Fabry-Perot cavity sensor based on an opened hollow-core anti-resonant fiber.

A new approach to conquer the thermal phase drift of an optical fiber Fabry-Perot interferometer (FPI) sensor is proposed and experimentally demonstrated. By employing a hollow-core anti-resonant fiber (HC-ARF) and optimizing the fusion splicing (includes mode field adaptation) between the lead-in single-mode fiber (SMF) and the HC-ARF, a high spectral resolution (λ/Δλ ≈ 3.8 × 104) optical fiber air-cavity FPI sensor with a fringe visibility higher than 7 dB is constructed. To eliminate the thermal phase drift (i.e. temperature crosstalk) of the sensor that originates from the intrinsic thermal expansion effect of the silica material of the HC-ARF, the FPI air cavity is connected to the external environments, by which the effect of air expelling from the cavity with temperature increasing can well compensate the temperature-induced cavity elongation. As a result, the thermal phase drift of the FPI is reduced to zero at a temperature range of ∼ 80-110 °C and within the temperature range of 40-80 °C, the thermal phase drift is still halved compared with the sealed FPI cavity. The nearly zero thermal phase drift of a FPI at such a temperature range has never been achieved before, to our best knowledge. As a proof of concept, a temperature-immune fiber-optic strain sensor is demonstrated. This work offers a new and efficient approach to eliminate the thermal phase drift (i.e. temperature crosstalk) of a fiber-optic device, which may significantly improve the measurement accuracy and detection limit of fiber-optic FPI sensors. Furthermore, the principle and schema can be generalized to a wide variety of fiber-optic devices.

Simulation of a micron resolution capillary liquid scintillation detector for 14 MeV fusion neutrons.

Aiming to improve the spatial resolution of a neutron imaging system (NIS) for 14 MeV fusion neutrons, an ideal micron resolution capillary detector filled with a high optical index liquid scintillator was simulated. A threshold for each capillary pixel and a threshold for each cluster were applied to suppress the gamma-induced background. In addition, by using a pattern recognition algorithm and an optimized Hough transform, the accuracy of determining the neutron impinging positions and the dynamic range of this detector were enhanced. For an ideal capillary array detector, the spatial resolution is expected as one capillary size of 20µm. The dynamic range of ∼1000 is reachable while the accuracy of neutron impinging position determination keeps better than 85%. The ionization quenching, light sharing and energy resolution of the detector were applied to the simulated data to understand the capillary array detector.

Proposal for complete characterization of attosecond pulses from relativistic plasmas.

In this study, we propose two full-optical-setup and single-shot measurable approaches for complete characterization of attosecond pulses from surface high harmonic generation (SHHG): SHHG-SPIDER (spectral phase interferometry for direct electric field reconstruction) and SHHG-SEA-SPIDER (spatially encoded arrangement for SPIDER). 1D- and 2D-EPOCH PIC (particle-in-cell) simulations were performed to generate the attosecond pulses from relativistic plasmas under different conditions. Pulse trains dominated by single isolated peak as well as complex pulse train structures are extensively discussed for both methods, which showed excellent accuracy in the complete reconstruction of the attosecond field with respect to the direct Fourier transformed result. Kirchhoff integral theorem has been used for the near-to-far-field transformation. This far-field propagation method allows us to relate these results to potential experimental implementations of the scheme. The impact of comprehensive experimental parameters for both apparatus, such as spectral shear, spatial shear, cross-angle, time delay, and intensity ratio between the two replicas has been investigated thoroughly. These methods are applicable to complete characterization for SHHG attosecond pulses driven by a few to hundreds of terawatts femtosecond laser systems.

Sound Velocities, Elasticity, and Mechanical Properties of Stoichiometric Submicron Polycrystalline δ-MoN at High Pressure.

Acoustic velocities and elasticity of stoichiometric submicron polycrystalline δ-MoN have been reported at high pressure using ultrasonic measurements and first-principles calculations. Using the finite-strain equation-of-state approach, the bulk modulus and shear rigidity, as well as their pressure derivatives, are derived from the current experimental data, yielding BS0 = 360.0(8) GPa, G0 = 190.0(5) GPa, ∂BS/∂P = 3.4(2), and ∂G/∂P = 1.4(1). Based on our experimental data and the velocity-elasticity correlated models, the mechanical/thermal properties (i.e., hardness, fracture toughness, Grüneisen parameter, Debye temperature, Poisson's ratio) are also derived. Interestingly, we find that hexagonal δ-MoN is almost as incompressible as superhard cubic boron nitride (cBN) (∼384 GPa) and its hexagonal ε-NbN (∼373 GPa) counterpart, and its shear rigidity (G = 190 GPa) is comparable to that of the superhard diamond composite (G = 204 GPa). Moreover, the fracture toughness of submicron δ-MoN polycrystals is achieved up to ∼4.3 MPa·m1/2, which is comparable to superhard diamond (4-7 MPa·m1/2) and cBN (2-5 MPa·m1/2). The Vickers hardness of submicron δ-MoN is estimated to be Hv ≈ 17.4 GPa using Chen's model, which is found to be almost as hard as hexagonal ε-NbN and δ-WN, and may be very important for its applications in extreme environments.

Temperature-Feedback Nanoplatform for NIR-II Penta-Modal Imaging-Guided Synergistic Photothermal Therapy and CAR-NK Immunotherapy of Lung Cancer.

In this study, to visually acquire all-round structural and functional information of lung cancer while performing synergistic photothermal therapy (PTT) and tumor-targeting immunotherapy, a theranostic nanoplatform that introduced upconversion nanoparticles (UCNPs) and IR-1048 dye into the lipid-aptamer nanostructrure (UCILA) is constructed. Interestingly, the IR-1048 dye grafted into the lipid bilayer can serve as the theranostic agent for photoacoustic imaging, optical coherence tomography angiography, photothermal imaging, and PTT in the second near infrared (NIR-II) window. In addition, loaded in the inner part of UCILA, UCNPs possess the superior luminescence property and high X-ray attenuation coefficient, which can act as contrast agents for computed tomography (CT) and thermo-sensitive up-conversion luminescence (UCL) imaging, enabling real-time tracking of metabolic activity of tumor and temperature-feedback PTT. Furthermore, under the complementary guidance of penta-modal imaging and an accurate monitoring of in situ temperature change during PTT, UCILA exhibits its excellent capability for ablating the lung tumor with minimal side effects. Meanwhile, synergistic CAR-NK immunotherapy is carried out specifically to eradicate any possible residual tumor cells after PTT. Therefore, the UCILA nanoplatform is demonstrated as a multifunctional theranostic agent for both penta-modal imaging and temperature-feedback PTT while conducting targeting immunotherapy of lung cancer.

Generation of necklace-shaped high harmonics in a two-color vortex field.

We numerically studied gas high-harmonic generation in a two-color vortex laser field using the non-adiabatic Lewenstein model. Macroscopic responses were calculated by numerically solving the three-dimensional propagation equation in cylindrical coordinates. It was confirmed that unique high-harmonic signals with necklace-like shapes exhibit orbital angular momentum (OAM). The azimuthally distributed necklace harmonics exhibit periodic modulation as a function of laser frequency and topological charges of the driving field. Phase investigation showed that the OAM of the necklace harmonics is attributable to the tuning of the relative intensity of the two driving pulses. These findings provide a new dimension for high-harmonic manipulation in the vortex field. The two-color vortex field is the first scheme proposed for manipulating the intensity profile of high harmonics.

Vortex laser beam generation from laser interaction with azimuthal plasma phase slab at relativistic intensities.

It is shown theoretically and by simulation that a Gaussian laser beam of relativistic intensity interacting with a uniform-thickness plasma slab of azimuthally varying density can acquire orbital angular momentum (OAM). During the interaction, the laser ponderomotive force and the charge-separation force impose a torque on the plasma particles. The affected laser light and plasma ions gain oppositely directed axial OAM, but the plasma electrons remain almost OAM free. High OAM conversion efficiency is achieved due to the strong azimuthal electromagnetic energy flow during the laser phase modulation. The present scheme should provide useful reference for applications requiring relativistic-intense vortex light.

High numerical aperture Hartmann wave front sensor for extreme ultraviolet spectral range.

We present a novel, to the best of our knowledge, Hartmann wave front sensor for extreme ultraviolet (EUV) spectral range with a numerical aperture (NA) of 0.15. The sensor has been calibrated using an EUV radiation source based on gas high harmonic generation. The calibration, together with simulation results, shows an accuracy beyond λ/39 root mean square (rms) at λ=32nm. The sensor is suitable for wave front measurement in the 10 nm to 45 nm spectral regime. This compact wave front sensor is high-vacuum compatible and designed for in situ operations, allowing wide applications for up-to-date EUV sources or high-NA EUV optics.

High selective detection of mercury (II) ions by thioether side groups on metal-organic frameworks.

Mercury ions can significantly affect the organism and environment even at a very low concentration. Thus, great efforts have been devoted to developing high sensitive electrochemical sensors, especially the one that not only detect the mercury ions but also effective sensitive to thymine-Hg2+-thymine in aqueous solution. Metal-organic-frameworks (MOFs) possess hollow nature and are easy for grafting functional groups, however, there is still no attempts for working as electrochemical sensors in detecting mercury ions. Herein, we report a novel type sensor of Zr(IV)-based MOFs with specifically attached thioether side groups allowing mercury ions to be easily adsorbed and detected. The Zr(IV)-involved MOFs show strong binding to mercury ions compared with the bare MOFs, as confirmed by both experiment measurements and theoretical calculations. The as-prepared senor is sensitive ranging from 0.01 nM to 3 µM with detection limitation of 7.3 fM, which is better than most of T-Hg2+-T- and enzyme-based sensors reported so far. The high sensitivity could be due to the straightforward adsorption pathway and the biomolecule exclusion nature of the Zr(IV)-involved MOFs sensor. We anticipate that our findings could pave the way for MOFs-based sensor exploration towards its commercial applications.

Large-scale synthesis of carbon dots/TiO2 nanocomposites for the photocatalytic color switching system.

In view of the easy control and contactless spatial nature of light, the photoreversible color switching system has attracted tremendous attention. Although some progress has been achieved in the past few years, the practical applications have been limited by the complicated preparation process, material toxicity and low reaction yield. Herein, we report a rapid, a one-pot large-scale synthesis approach for the preparation of carbon dots (CDs)/TiO2 nanocomposites via the thermal condensation at 160 °C, affording high photocatalytic color switching on/off performance. Under ambient conditions and with the introduction of some oxygen gas, MB rapidly changed from blue to colorless in one minute under UV-vis irradiation and recovered (again showed its original blue color) in twenty minutes. We anticipate that the designed low-cost and green carbon dots (CDs)/TiO2 nanocomposites have much potential in practical applications and represent a solid step toward color switching applications.

Multiple effects of gradient coupling on network synchronization.

Recent studies have shown that the synchronizability of complex networks can be significantly improved by gradient or asymmetric couplings, and increase of the gradient strength could enhance the network synchronizability monotonically. Here we argue and demonstrate that, for a typical complex network, there could be an optimal gradient where the maximum network synchronizability is achieved. That is, large gradient may deteriorate synchronization. We attribute the suppressing effect of gradient coupling to the phenomenon of network breaking and show that, comparing with sparse homogeneous networks, dense heterogeneous networks suffer less from network breaking and, consequently, benefit more from large gradient in improving synchronization. The findings are supported by indirect simulations of eigenvalue analysis and direct simulations of coupled nonidentical oscillators.

Model-based detector and extraction of weak signal frequencies from chaotic data.

Detecting a weak signal from chaotic time series is of general interest in science and engineering. In this work we introduce and investigate a signal detection algorithm for which chaos theory, nonlinear dynamical reconstruction techniques, neural networks, and time-frequency analysis are put together in a synergistic manner. By applying the scheme to numerical simulation and different experimental measurement data sets (Henon map, chaotic circuit, and NH(3) laser data sets), we demonstrate that weak signals hidden beneath the noise floor can be detected by using a model-based detector. Particularly, the signal frequencies can be extracted accurately in the time-frequency space. By comparing the model-based method with the standard denoising wavelet technique as well as supervised principal components analysis detector, we further show that the nonlinear dynamics and neural network-based approach performs better in extracting frequencies of weak signals hidden in chaotic time series.

Generation of strong quasistatic magnetic fields in interactions of ultraintense and short laser pulses with overdense plasma targets.

An analytical fluid model is proposed for the generation of strong quasistatic magnetic fields during normal incidence of a short ultraintense Gaussian laser pulse with a finite spot size on an overdense plasma. The steepening of the electron density profile in the originally homogeneous overdense plasma and the formation of electron cavitation as the electrons are pushed inward by the laser are included self-consistently. It is shown that the appearance of the cavitation plays an important role in the generation of quasistatic magnetic fields: the strong plasma inhomogeneities caused by the formation of the electron cavitation lead to the generation of a strong axial quasistatic magnetic field Bz. In the overdense regime, the generated quasistatic magnetic field increases with increasing laser intensity, while it decreases with increasing plasma density. It is also found that, in a moderately overdense plasma, highly intense laser pulses can generate magnetic fields approximately 100 MG and greater due to the transverse linear mode conversion process.